Adverse Drug Reactions: Mechanisms and Management
9781779568403
pages
Arcler Education Inc
Overview
Adverse drug reactions (ADRs) range from predictable pharmacologic effects to rare immune-mediated or idiosyncratic responses that can cause significant morbidity. Understanding the mechanisms behind ADRs—pharmacokinetic interactions, hypersensitivity pathways, and genetic susceptibilities—is key to prevention and safe prescribing. This book explains the biological and clinical bases of ADRs, grouping reactions by mechanism and organ system involvement. Practical sections cover risk assessment, monitoring strategies, deprescribing, and stepwise management of acute drug reactions. It includes guidance on reporting systems, pharmacovigilance, and how to counsel patients about risks and alternatives. Designed for clinicians, pharmacists and trainees, the text balances mechanistic depth with actionable clinical algorithms.
Author Bio
Dr. Shubham Sewariya is a Research Scientist at the University of Delhi, India, with expertise in medicinal chemistry and drug discovery. His research focuses on developing novel anticancer drug leads by combining synthetic chemistry, biological insights, and computational approaches. He holds an Integrated BS–MS degree in Chemistry from the Indian Institute of Science Education and Research (IISER), Thiruvananthapuram, and has completed his Ph.D. jointly at University of Delhi and the University of Lancashire, UK. His doctoral work centers on the discovery and development of secondary metabolites, including noscapinoids and coumarins, as potential anticancer agents. Dr. Sewariya has received several prestigious fellowships and awards, including the Commonwealth Split-site PhD Scholarship (2023–24) funded by the UK Foreign, Commonwealth & Development Office, the CSIR Senior Research Fellowship, and the INSPIRE SHE Fellowship from Department of Science and Technology, Govt of India. He has also presented his work at international platforms such as the American Chemical Society (ACS) conferences in San Francisco and Chicago. With more than a dozen peer-reviewed publications, his contributions span synthetic chemistry, nanomedicine, and biophysical studies, particularly in designing intelligent nanocarriers and molecular probes for cancer therapy. Beyond the laboratory, Dr. Sewariya is deeply committed to advancing translational research that bridges science and medicine for the betterment of human health.
